Chronic Low-grade inflammation (CLGI
This is long-term, low-level inflammation that doesn’t cause obvious symptoms at first, but slowly damages the body over time. It’s not caused by an infection but by stress, lifestyle, diet, and underlying conditions.
Index:
- Common names
- What can cause CLGI
- Related conditions and their Suggested Protocols
Common names for CLGI include:
- Chronic systemic inflammation
- Subclinical inflammation
- Metaflammation (short for metabolic inflammation)
- Inflammaging (when referring to age-related chronic inflammation)
What can cause CLGI
Prolonged Stress
Chronic stress increases hormones like cortisol, which weakens the immune system and causes a chain reaction:
- Inflammation increases.
- Leads to stress inflammation, which aggravates metabolic and mental health disorders.
Unhealthy Lifestyle ("Adeomes")
This includes:
- Poor sleep
- Lack of exercise
- Poor diet
- Exposure to toxins (e.g., pollution, smoking, medications)
These factors contribute to inflammation and weaken your body’s defenses, increasing the risk of disease.
Obesity & Adipose (Fat) Tissue Dysfunction
Fat tissue isn’t just storage; it releases hormones and immune signals.
When there’s too much fat or it becomes dysfunctional:
- It produces inflammatory chemicals.
- It can interfere with insulin, leading to insulin resistance and metabolic syndrome.
Related conditions and their Suggested Protocols
Insulin Resistance
Inflammation affects how cells respond to insulin.
- Sugar stays in the blood instead of entering cells.
- This can lead to type 2 diabetes over time.